Institutional filer · SEC 13F · Q1 2024
Opaleye Management Inc.
The reported 13F portfolio of Opaleye Management Inc. (CIK 1595855) - top holdings, how concentrated the book is, and what changed last quarter.
- $458.9M
- Reported book
- 52
- Positions
- #111
- of 360 filers
The verdict
According to SEC Form 13F-HR filings in this corpus, Opaleye Management Inc. ranks #111 of 360 institutional filers by reported book value (largest first), matching the /funds listing. As of Q1 2024 the reported book is $458.9M across 52 positions, a moderately concentrated portfolio.
- $458.9M
- reported 13F value
- 52
- disclosed positions
- 13.2%
- in OCULAR THERAPEUTIX INC
- #111
- of 360 filers
Top-5 share 42.2% → MID-PACK book (largest five positions vs the rest of the reported 13F book).
According to SEC Form 13F-HR filings in this corpus, Opaleye Management Inc. ranks #111 of 360 institutional filers by reported book value (largest first), matching the /funds listing.
Where Opaleye Management Inc. sits by disclosed position count
Opaleye Management Inc. reports 52 13F positions among 360 filers with holdings (inventory signal, not a quality ranking). Orthogonal to book-value rank.
Opaleye Management Inc. vs all filers by holding count
Where this filer's disclosed position inventory sits among every tracked 13F manager
52 263rd of 360 higher than 97 of 360 filers
Filers, banded by disclosed position count
Each bar is a band; taller bars hold more filers. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source SEC Form 13F-HR filings · 2026-05-16
Concentration vs. book size among peer filers
Opaleye Management Inc. reports $0.46B across 52 disclosed positions, tracking the median among similarly sized peer filers on position count.
Reported book value vs. disclosed position count
How 13F filings are computed · All institutional filers · Largest filers by value
SEC Form 13F-HR filing desk
CIK 1595855 · Q1 2024 $459M book
BOOK-MID · POS-FOCUS · CONC-HEAVY · LEAD-HEAVY · PHOTO-FINISH · TREND-FLAT · FY-SNAPSHOT
- BOOK-MID #111/360
- POS-FOCUS 52 names
- CONC-HEAVY 42% top-5
- LEAD-HEAVY 13.2% top
- PHOTO-FINISH Cherry Tree Wealth ,
- TREND-FLAT Book steady
- FY-SNAPSHOT Q1 2024
Photo-finish peer on reported book: Cherry Tree Wealth Management, LLC
Read with: Institutional investor types - Manager type shapes what a 13F book represents — RIAs, hedge funds, and banks file the same form differently.
Reported-book neighbourhood · Opaleye Management Inc.
Nearest tracked filers by aggregate 13F reported book, not a full corpus reprint.
How the reported book breaks down
$458.9M decomposed into the top 5 reported positions (shown below) versus every other disclosed position.
Top Reported Holdings
| # | Security | Value | % of book |
|---|---|---|---|
| 1 | OCULAR THERAPEUTIX INC | $60.5M | 13.2% |
| 2 | HARROW HEALTH INC | $51.9M | 11.3% |
| 3 | TG THERAPEUTICS INC | $34.7M | 7.6% |
| 4 | KEROS THERAPEUTICS INC | $24.3M | 5.3% |
| 5 | RHYTHM PHARMACEUTICALS INC | $22.3M | 4.9% |
| 6 | CATALYST PHARMACEUTICALS INC | $16.0M | 3.5% |
| 7 | ARVINAS INC | $13.6M | 3.0% |
| 8 | IOVANCE BIOTHERAPEUTICS INC | $13.3M | 2.9% |
| 9 | JASPER THERAPEUTICS INC | $12.8M | 2.8% |
| 10 | EDGEWISE THERAPEUTICS INC | $12.1M | 2.6% |
| 11 | APPLIED THERAPEUTICS | $12.0M | 2.6% |
| 12 | 4D MOLECULAR THERAPEUTICS INC | $11.0M | 2.4% |
| 13 | CODEXIS INC | $10.9M | 2.4% |
| 14 | PROTARA THERAPEUTICS INC | $10.8M | 2.4% |
| 15 | ACELYRIN INC | $10.7M | 2.3% |
| 16 | CRINETICS PHARMACEUTICALS INC | $9.8M | 2.1% |
| 17 | ETON PHARMACEUTICALS INC | $9.2M | 2.0% |
| 18 | TREVI THERAPEUTICS INC | $9.1M | 2.0% |
| 19 | LYELL IMMUNOPHARMA INC | $7.5M | 1.6% |
| 20 | NEWAMSTERDAM PHARMA COMPANY | $7.5M | 1.6% |
| 21 | VENTYX BIOSCIENCES INC | $7.1M | 1.5% |
| 22 | INTELLIA THERAPEUTICS INC | $7.0M | 1.5% |
| 23 | COMPASS THERAPEUTICS INC | $6.3M | 1.4% |
| 24 | XOMA CORP DEL | $6.0M | 1.3% |
| 25 | LIQUIDIA CORPORATION | $5.8M | 1.3% |
Frequently Asked Questions
- How big is Opaleye Management Inc.'s 13F portfolio?
- Opaleye Management Inc. reports $458.9M of long US-equity positions across 52 securities as of Q1 2024. This reflects 13F-disclosed holdings only, it is not the firm's total assets under management.
- Where does Opaleye Management Inc. sit among tracked 13F filers?
- According to SEC Form 13F-HR filings in this corpus, Opaleye Management Inc. ranks #111 of 360 institutional filers by reported book value (largest first), matching the /funds listing. The ordinal is recomputed live from filers with reported book value > 0. See /methodology/#corpus-placement.
- What is Opaleye Management Inc.'s largest position?
- Opaleye Management Inc.'s largest reported position is OCULAR THERAPEUTIX INC at $60.5M, about 13.2% of its reported book as of Q1 2024.
Nationwide filers with similar book size or holding count
Two 13F-derived peer sets for Opaleye Management Inc.: nearest reported book value and nearest holding inventory, not catalog browse links.
Similar reported book
Nearest filers by reported long-equity book ($458.9M here).
Similar holding count
Nearest filers by number of disclosed positions (52 here).
Using this filing
- The rankings sort every tracked filer the same way Opaleye Management Inc. was placed above, so you can see exactly how the rest of the field compares. View the rankings
- Cherry Tree Wealth Management, LLC reported the nearest book value ($455.5M) this quarter, a useful scale comparison for Opaleye Management Inc.. Compare filers
- 13F-HR reports long US-listed equity positions only, not total AUM, short positions, or non-equity holdings, treat the reported book as a partial picture. Read the methodology
Form 13F-HR discloses long US-listed equity positions of managers with $100M+ qualifying assets, filed within 45 days of period end. Reported value is not total AUM.
Source: U.S. Securities and Exchange Commission (SEC) - EDGAR Form 13F-HR institutional holdings filings · Q1 2024 13F-HR discloses long US-listed equity positions of managers with $100M+ qualifying assets, filed within 45 days of period end. Reported value is not total AUM.
PlainFundData is rendered directly from SEC EDGAR Form 13F-HR institutional holdings filings, no number is typed in by an editor. Filer holdings, changes, and reported book on this page are aggregated live from those 13F-HR extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-16.